Endocrine Abstracts

Objective: Diabetes mellitus (DM) is a complex disease that affects many systems. The most important cells of the immune system are lymphomononuclear (LMN) cells. Here, we aimed to evaluate the energy metabolism of LMN cells in patients with diabetes and impaired glucose tolerance.Methods: We measured LMN cell energy metabolism in patients with type 2 diabetes mellitus, impaired glucose tolerance (IGT) and healthy subjects. Cells were freshly isolated fr...

Aim: The prevalence of overweight and obesity is increasing and becoming a global health problem. Obesity is the cause of increased cardiovascular morbidity and mortality and psychosocial problems. There are several reports which mentioning the unfavourable effects of aggressive weight loss regimes on the immune system. This study was designed to search for the effect of a straightforward, controlled and permanent weight loss program on the immune system.<p class="abstext"...

Objective: Visfatin, a novel adipocytokine, is predominantly expressed in visceral fat and correlated with obesity. The pathophysiologic role of visfatin in metabolic syndrome (MS) is not clear. We aimed to investigate the relationship between plasma visfatin levels and components of MS, and also the effect of therapeutic lifestyle change (TLC) on these parameters.Design and methods: Nineteen patients (5 male, 14 female; mean age 51.0±9.3 years; bod...

Objective: The pleiotropic functions of statins are crucial in reducing cardiovascular events. There is controversy about their effects on insulin resistance. The aim of this study was to investigate the effect of Fluvastatin treatment on plasma adiponectin and insulin levels in a group of dyslipidemic population who had no confounding factors for insulin resistance such as diabetes or hypertension.Design and methods: Forty nine (27 male, 22 female; mean...